The rate is improved survival of patients with breast cancer?

There is a new study showing that the survival rate of women with recurrent breast cancer has been improving in the last two decades, but also cautions that more studies are needed.

Sharon H. Giordano, MDLa lead author and assistant professor in the Department of Breast Medical Oncology at M. D Anderson answered several questions hacerca of this study.

What was the goal of this destudio?

The goal of this study was to determine whether the survival rate in patients with recurrent breast cancer had improved (the recurrent cancer is cancer that returns after his initial diagnosis).

As obtained that information?

The researchers analyzed data from 834 patients of M. D Anderson who had had recurrent cancer developed between th December 1974 and November 2000.

The major objective of this study was to evaluate the association between the year in which recurrence was detected and subsequent survive. Patients were divided into five groups basing on the year in which occurred recurrence, and survival was compared between these five groups.

They found?

Although our findings are suggestive and not conclusive, our data suggest that the prognosis of patients with recurrent breast cancer has improved from 1974 to 2000.

Our analysis shows that there is a significant improvement in survival rates over the five groups, in more recent patients who live more noticeable after diagnosis of recurrence.

The following are the survival rates were diagnosticaos patients with recurrent breast cancer and specific period:

* 10% for 1974-1979 patients
* 14% for 1980-1984 patients
* 22% for 1985-1989 patients
* 29% for 1990-1994 patients
* 44% for 1995-2000 patients

The more recent the recurrence group had better prognostic variables, and a longer life span, this is due in part to advances in drugs and treatments. The most favorable variables include:

* A smaller size of the tumor
• A lower level of disease status
* Less involved lymph nodes
* Disease-free interval longer
* Tumors with positive estroneno receptors (these are tumors that use estrogen to grow).
* Tumors that do not involve major organs

It is estimated that there has been a risk reduction of 1% to 2% for each year it increases, although the change was not statistically highly significant. This statistic is consistent with data Seet (database of the results found by the National Cancer Institute Surveillance, Epidemilogy and End Results)

That current statistics indicate breast cancer?

In 2004, approximately 217.440 new cases of breast cancer were diagnosed in the United States, and 40.580 women are expected to die due to metastasis, this according to the American Cancer Society.

How conclusive are the results?

Due to the inherent difficulties faced in determining changes in survival time, we urge that these results are interpreted cautiously.

Although the strength of this study includes a large patient poblacin is needed extensive follow up (mean 9.3 years) and uniform initial stages follow-up tests, the study is limited to the problems inherited in elanalisis of survival data time.

For example, improvements in radiographic techniques and more precise imaging techniques may change the distribution of the phases. Small metastases that may have been detected with modern imaging techniques 90 could have passed without notice in the ’70s. Thus some patients were diagnosed at 70 could have been bad clasificdos saying Dela had early disease. This would result in apparent poorer prognosis of the patient group in 1970.

In addition, improvements in radiographic imaging could have resulted in more diagnoses of recurrent disease temprenaos. This could give a misleading appearance of improved survival.

What could be responsible for increasing survival?

There has been a marked increase through time on the number of drugs available to treat cancer. One of the largest increases took place in the decade of the 90s with drugs such as taxanes, vinorelbine, capecitabine, Herceptin, aromatase inhibitors and pamidronate.

Therapeutic advances have also been having an impact on the survival rate among women with breast cancer. For example, two began in the early tests involving 70 adjuvant chemotherapy (chemotherapy before surgery) these treatments were shown to have adjuvant chemotherapy buenosresultados as to the time improvement and disease-free survival.

As this study will help future research?

Regardless of progress, the improvements in survival rates in patients with recurrent breast cancer or metastatic have been difficult to establish.

The mortality of breast cancer has been in decline. From 1995-1999, rates of breast cancer have declined about 3.2% a year. But still remains not clear whether eldescenso of deaths from cancer are due to a higher proportion of patients diagnosed with early stages of the disease or improvement in treatment.

With these data, we urge them to become more recurdos to clarify whether advances in therapy have led the desupervivencia improvements in the rate of recurrent breast cancer women.

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